Item Long chain fatty acid activation, entry into mitochondria and metabolism via fatty acid oxidation. Public Library of Science Figshare The Role of l Carnitine in Mitochondria, Prevention of Metabolic Inflexibility and Disease Initiation Fatty Acid Transport an overview ScienceDirect Topics Frontiers Carnitine Palmitoyltransferase System: A New Target for Anti Inflammatory and Anticancer Therapy? Oxidation of Fatty Acids: Ketogenesis Basicmedical Key Short Note On Carnitine Shuttle: Fatty acids are oxidized in mitochondria, and synthesized in the cytoplasm. Long chain fatty acids must form an active intermediate, fatty acyl CoA, before being oxidized inside mitochondria. Catherine